Dextran Sulfate Sodium Salt (DSS) - Colitis Grade (36,000-50,000 MW)
Product Description
Dextran sulfate sodium salt, or DSS, is a branched glucan that triggers colitis in mice and rats when administered in drinking water. DSS binds to medium-chain-length fatty acids in the colon and induces intestinal inflammation. Dextran sulfate sodium is also used to precipitate lipoproteins and to release DNA from DNA-histone complexes.
Application Notes
Dextran Sulfate Sodium (DSS) is proven to have versatile value in biomedical/clinical research. DSS can be used to study colitis (Inflammatory Bowel disease) in research animals and can also be used as an antiviral agent. Inflammatory Bowel Disease (IBD) is characterized by chronic and relapsing inflammation of the gastrointestinal tract and is associated with increased risk of developing colitis-associated cancer. Several animal models have been used to study colitis and one such method involves the oral administration of dextran sulfate sodium (DSS) in the drinking water of mice, leading to chronic colitis. This DSS induced colitis model is spontaneous and is used to assess the therapeutic potential of treatments for IBD. Bamba et al (2012) performed a comparative analysis of 3 different DSS preparations to examine the chemical and cytotoxic properties, as well as the severity of colitis. Their study concluded that the DSS from MP Bio induced severe colitis as indicated by body weight transition, DAI score, colon weight/length and histological scores. This DSS is well characterized and offers the highest sulfur content (19%), highest chirality (+104 ° of specific rotation), and lowest pH (6.2 at 1% solution).
Usage Statement
Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals
Key Applications
Colitis, Antilipemic
| SKU | 02160110-CF |
| Alternate Names | DSS, Dextran Sodium Sulfate, Dextrane Sulfate Sodium Salt |
| Application Notes | Dextran Sulfate Sodium (DSS) is proven to have versatile value in biomedical/clinical research. DSS can be used to study colitis (Inflammatory Bowel disease) in research animals and can also be used as an antiviral agent. Inflammatory Bowel Disease (IBD) is characterized by chronic and relapsing inflammation of the gastrointestinal tract and is associated with increased risk of developing colitis-associated cancer. Several animal models have been used to study colitis and one such method involves the oral administration of dextran sulfate sodium (DSS) in the drinking water of mice, leading to chronic colitis. This DSS induced colitis model is spontaneous and is used to assess the therapeutic potential of treatments for IBD. Bamba et al (2012) performed a comparative analysis of 3 different DSS preparations to examine the chemical and cytotoxic properties, as well as the severity of colitis. Their study concluded that the DSS from MP Bio induced severe colitis as indicated by body weight transition, DAI score, colon weight/length and histological scores. This DSS is well characterized and offers the highest sulfur content (19%), highest chirality (+104 ° of specific rotation), and lowest pH (6.2 at 1% solution). |
| Boiling Point | 310 ° C |
| Grade | Colitis grade |
| Applications | Colitis, Antilipemic |
| MDL # | MFCD00081551 |
| Melting Point | 92 ° C |
| Molecular Weight | 165.192 g/mol |
| Pack Size | No |
| Personal Protective Equipment | Eyeshields, Gloves, respirator filter |
| Physical Appearance | White Powder |
| Product Families Description | Dextran sulfate sodiium salt |
| Product Overview | Dextran Sulfate Sodium Salt (36,000-50,000 M.Wt.) Colitis Grade |
| References | <p>Kinchen, J. Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease. Cell. 2018, 175, 372-386.<br>Mahalhal , A. Oral iron exacerbates colitis and influences the intestinal microbiome, PLOS ONE. 2018, 13, e0202460.<br>Dokoshi, T. Hyaluronidase inhibits reactive adipogenesis and inflammation of colon and skin. JCI Insight. 2018, 3, e12307.<br>Zhu, H. RNA virus receptor Rig-I monitors gut microbiota and inhibits colitis-associated colorectal cancer. J. Exp. Clin. Cancer Res. 2017, 36, 2.<br>Monticelli, L. IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin–EGFR interactions. PNAS. 2015, 112, 10762-10767.</p> |
| Residue on Ignition | <50% |
| RTECS Number | HH9290000 |
| Solubility | >24.8 [ug/mL] |
| Storage and Handling | Store at Room Temperature (15-30 ° C) |
| Usage Statement | Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals |
| Vapor Pressure | 2.6 x 10-4 mm Hg at 25 ° ° C (Estimated) |