Dino

α2-Macroglobulin

α2-Macroglobulin

Synonyms α2-M;α2-Macroglobulin

CAS Number: Not applicable

MDL Number: MFCD00130472

Packaging size: 5 mg

SKU 0219134505
Price:
CN¥726.25
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Description

Product Description

α2-Macroglobulin

Application Notes

α2-Macroglobulin inhibits all classes of endoproteases by forming a complex with the protease. When the protease cleaves the macroglobulin "bait" sequence, the macroglobulin rearranges and traps the protease. It inhibits bromelain, chymotrypsin, elastase, endoproteinase Arg-C, endoproteinase Glu-C, ficin, papain, plasmin, subtilisin, thermolysin, thrombin, and trypsin. It is known to inhibit neurite outgrowth by blocking the activity of b-nerve growth factor.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Inhibitor

Specifications
SKU 0219134505
Analysis Note Prepared from plasma that was shown to be non-reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
Application Notes α2-Macroglobulin inhibits all classes of endoproteases by forming a complex with the protease. When the protease cleaves the macroglobulin "bait" sequence, the macroglobulin rearranges and traps the protease. It inhibits bromelain, chymotrypsin, elastase, endoproteinase Arg-C, endoproteinase Glu-C, ficin, papain, plasmin, subtilisin, thermolysin, thrombin, and trypsin. It is known to inhibit neurite outgrowth by blocking the activity of b-nerve growth factor.
Biochemical Physiological Actions One mg of α2-macroglobulin will inhibit a minimum of 10 μg trypsin with an activity of 10,000 BAEE un/mg protein. α2-Macroglobulin is found abundantly in plasma and interstitial fluids. The protease-α2-M balance plays an important role in mediating inflammatory tissue destruction. Serum levels of α2-M and protease-α2-M complexes are increased in patients with sepsis, emphysema, periodontitis, rheumatoid arthritis, and other inflammatory diseases, and oxidant inactivation of α2-M may contribute to tissue destruction during inflammation.
Format Crystalline powder
Formulation Details Lyophilized from 490 µL 30 mM Na phosphate; pH 7.0 and 10 mg Glucine and 1 mg glycine.
Applications Inhibitor
Pack Size 5 mg
Physical Appearance White Crystalline Powder
Product Families Description α-2-Macroglobulin
Product Overview α2-Macroglobulin
Purity ≥95% (SDS-PAGE)
Source Human plasma
Storage and Handling Store at -20 °C.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.